Abstract
The RCAS-TVA gene transfer system is based on a recombinant avian leucosis virus which is produced by the replication-competent avian splice acceptor vector, RCAS, and requires the presence of the avian subtype A receptor, TVA, for infection. Mammalian cells can be infected, however this requires these cells to be engineered to express the TVA receptor. Significant biosafety features include the virus being replication competent only in avian cells as there is inefficient viral assembly in mammalian cells even in those modified for infection.
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