Abstract
Fever and neutropenia is common complication of chemotherapy for pediatric malignancy and conditioning for hematopoietic stem cell transplantation. The epidemiology of fever and neutropenia has evolved over decades and the majority of infections are related to gram-positive organisms. The pediatric evidence base for prevention as well as for empirical antibiotic and antifungal therapy has improved greatly since the turn of the century. Current practices allow for variation in supportive care measures depending on the underlying severity of neutropenia.
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