Abstract
The length of time and temperature of storage can potentially have a significant impact on the stability of the drug and its measured concentration. It is, therefore, imperative that one be aware of potential changes in drug concentrations due to instability when interpreting the toxicological result. Drug concentrations may increase or decrease during the storage interval; depending upon storage conditions, especially temperature and/or length of time, these changes may be substantial. The stability of drugs may be due to chemical instability and/or mediated by bacteriological activity. The chemical structure of the compound may be used to predict instability; drugs with ester linkages, containing a ringed heteroatom or have a functional group susceptible to oxidation or reduction may exhibit instability upon storage.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
