Abstract
Toxicological analyses play a critical role in the determination of the cause and manner of death. However, as critical as the toxicological testing phase is, the preanalytical phase that is the specimen collection method and/or storage can have a significant impact on the toxicological results, thus adding additional complexities to the interpretation. Drug concentrations may change due to the specimen collection process, the storage container the specimen is held in and the storage conditions for the specimen(s). The storage container may add, form or remove target analytes to or from the specimen. The storage conditions can influence not only the stability of the biological matrix itself, but also the stability of the drug in the specimen. Changes in drug concentrations and/or target analytes found in the specimen could lead to misinterpretation of the toxicological test results and potentially change the determination of the cause and manner of death.
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