Abstract
8 - An internal cross-linked polymeric nanoparticle with dual sensitivity for combination therapy of muscle-invasive bladder cancer
Highlights
Bladder cancer, usually originates from the epithelial lining of a urinary bladder, is one of the most common malignancies of the urinary system [1,2,3]
The DOX&IR780@PEG-PCL-SS NPs were synthesized using internal cross-linking strategy to increase the stability of nanoparticles
Given the excellent tumor-targeting ability and negligible toxicity to normal tissue, DOX&IR780@PEG-PCL-SS NPs can greatly increase the concentration of the anti-cancer drugs in tumor cells
Summary
Usually originates from the epithelial lining of a urinary bladder, is one of the most common malignancies of the urinary system [1,2,3]. 75% of patients present non-muscle invasive bladder cancer (NMIBC) and 20% present muscle invasive bladder cancer (MIBC). NMIBC recurs at a rate of 50–80% and has a 14% chance of progression to muscle-invasive cancer after transurethral resection (TUR) alone[4]. Radical total cystectomy is almost inevitable in muscle-invasive bladder cancer. Patients with bladder tumor resection still have a high risk of death and will reduce the quality of life of patients [5]. Radical surgery combined with systemic chemotherapy is routinely used for muscle-invasive bladder cancer[6]. Photothermal therapy (PTT) shows strong promise for treating tumors. PTT makes photosensitizers generate heat from light absorption, which can cause cellular necrosis and apoptosis and shows a high therapeutic efficacy for tumor ablation [7,8,9,10]. It is of great significance to overcome these limitations and improve the treatment effect of bladder cancer
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