796 ECRG4 regulates neutrophil responsiveness to proinflammatory signals during recruitment to infection

Abstract

Rapid neutrophil recruitment to cutaneous injury is critical for controlling local infection and preventing systemic dissemination. Neutrophils are mobilized from bone marrow reserves and home to vasculature near the source of inflammation, where they extravasate and migrate to the site of injury. We found that Esophageal Cancer Related Gene 4 (ECRG4), a leukocyte surface protein, amplifies early neutrophil recruitment to injury and hypothesized that ECRG4 may be important for the inflammatory response to infection through its ability to regulate neutrophil recruitment.