Abstract
Background and Aim: Gene therapy is still hampered by its lack of an ideal vector that can efficiently deliver therapeutic genes into target cells and, at the same time, without causing severe side effects. Cell-permeable peptides (CPPs) are some short polybasic peptides that are capable of penetrating cell or nucleus membrane in a receptor- and energy- independent way. Although several CPPs have successfully mediated gene delivery into different cells in vitro and in vivo, their application in hepatocytes is scarce. The aim of this study is to design and test prospective CPPs to mediate efficient gene delivery into hepatocytes in vitro and in vivo.
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