Abstract
20 children with Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) were seen over an 18 month period; 12 cases occurred during one month suggesting a mini-epidemic. Originally very ill patients were treated with prednisone which controlled the process, including pericarditis with tamponade, within 12 hours. The syndrome was also found to respond well to aspirin . Initially patients do not absorb aspirin sati sfactorily, resulting in low serum levels and lack of therapeutic response. Doses as high as 185 mg/kg/day of aspirin may be required to achieve a therapeutic blood level and excellent response. We now initiate therapy with 150 mg/kg/day in 6 divided doses. As the patients improve, aspirin absorption returns to normal and the dose is lowered to around 100 mg/kg/day. These observations have led to reduction in hospitalization from weeks to days, and more recently, with ease of prompt diagnosis, to out-patient management of early cases.
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