78-OR

Abstract

Objectives Impaired uterine invasion by extravillous trophoblast (EVT) during early pregnancy is implicated in the genesis of PE. However, reasons for EVT dysfunction are unclear due to virtually complete lack of early placental tissue from women who develop PE and absence of suitable animal models. Our objective was to investigate whether deficient endometrial maturation, i.e., “decidualization” antedated restricted EVT invasion in women who developed PE. Methods Bioinformatics and systems biology approach. Results We identified 396 differentially expressed genes (DEG) in chorionic villous samples (CVS) from women at ∼11 gestational weeks who developed severe PE 6 months later compared to CVS from normal pregnancies. A large number, 154 or 40%, overlapped with DEG associated with various degrees of decidualization before or after implantation as identified by other microarray datasets (p Conclusions Taken together, these results suggest that insufficient or defective maturation of endometrium and decidual NK cells before and during early pregnancy preceded aberrations of EVT invasion in women who developed PE. Disclosures M.B. Rabaglino: None. E.D. Post Uiterweer: None. A. Jeyabalan: None. W.A. Hogge: None. K.P. Conrad: None.