Abstract
Fibrosis is characterized by collagen deposition, fibro/myofibroblast accumulation, and extracellular matrix remodeling. Fibrosis can be seen in autoimmune diseases where it may be widespread and affect organs beyond the skin, with high morbidity and mortality, and no effective treatment. In cutaneous lupus, scar formation after discoid lesion eruption may evolve from enhanced fibrotic phenotypes. Our research has shown that epidermal-directed overexpression of murine Vgll3 causes severe lupus-like skin lesions suggestive of discoid lupus erythematosus (DLE).
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