Abstract
This chapter discusses the methodology for the purification of mouse immune interferon that separates it from some of the other well-characterized lymphokines. Data on the use of the partially purified interferon for antibody production are presented for the purpose of characterizing mouse immune interferons that are produced under various conditions. The immune (type II) interferons are induced under a variety of conditions, in primed lymphocytes with specific antigens or in unprimed lymphocytes with T cell mitogens. Newcastle disease virus (NDV)-induced L cell interferon, interferon induced in mouse peripheral leukocytes stimulated with NDV, and interferon induced in mice by lipopolysaccharide (LPS) are all neutralized by anti-L cell interferon. The anti-immune interferon serum did not affect these interferons. In an effort to determine whether immune interferons induced in various ways are neutralized equally well by anti-immune interferon, relatively constant amounts of various interferons were mixed with different dilutions of the antiserum.
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