77-OR: Circulating MicroRNAs Predict Glycemic Improvement and Response to a Behavioral Intervention

Abstract

Introduction: MicroRNAs (miRs) may be important regulators of risk for type 2 diabetes (T2D). The purpose of this study was to assess whether circulating miRs predicted glycemic improvement and responses to a behavioral intervention over 12 months. Methods: The study included 82 participants from a previously completed trial (PRYSMS study) that tested the effect of restorative yoga vs. stretching among overweight and inactive individuals with prediabetes and the metabolic syndrome, which found significant improvements in fasting blood glucose (FBG) after 12 months of yoga intervention. Circulating miRs were measured using flow cytometry. Linear models were used to determine the optimal sets of miR predictors. Results: Subsets of miRs were significant predictors of FBG (R2=0.754, p<0.001) and change in FBG over 12 months (R2=0.731, p<0.001) in the overall sample. Three miRs (let-7c, miR-363, miR-374b) were significant among the control group only for both FBG outcomes. There was no significant interaction by intervention group. Among the identified miRs, several have previously been associated with risk for T2D and related complications. Conclusions: This is one of the first studies to use a longitudinal design to assess whether miRs predict changes in FBG over time. Exploration of the function of the identified miRs may provide new insights about the etiology of T2D and responses to behavioral risk reduction interventions. Disclosure E. Flowers: None. I. D. Allen: None. A. M. Kanaya: None. B. Aouizerat: None. Funding National Center for Advancing Translational Sciences (KL2TR000143); National Center for Complementary and Alternative Medicine (R01AT004569); National Institute of Diabetes and Digestive and Kidney Diseases (R21DK117346); National Heart, Lung, and Blood Institute (2K24HL112827)