769 Is There Somatic Hypersensitivity and Central Sensitization in Functional Dyspepsia (FD)?

Abstract

Results: Compared to BBDR rats (n=5), LMMP preparations from normoglycemic BBDP rats (n=8) had higher MPO levels (0.0±0.0 vs. 5.4±2.2 U/mg, p<0.01), lower GRP78 mRNA expression (1.0±0.1 vs. 0.5±0.1, p<0.01) and lower PERK mRNA expression (1.0±0.1 vs. 0.4±0.2, p<0.05). A significant linear correlation was obserbed between mucosal and LMMP expression of GRP78 mRNA (p<0.01, r = 0.72; Figure1). In LMMP, a significant linear correlation was also observed between MPO levels and GRP78 mRNA expression (p<0.05, r = -0.65). Compared to BBDR rats, BBDP rats had lower mucosal GRP78 mRNA expression (1.0±0.1 vs. 0.4±0.1, p<0.001), lower IREα mRNA expression (1.0±0.2 vs. 0.5±0.1, p= 0.07), lower IREβ mRNA expression (1.0±0.2 vs. 0.3±0.2, p<0.01) and lower PERK mRNA expression (1.0±0.2 vs. 0.3±0.1, p<0.01). Conclusion: ER stress response was impaired in the inflamed intestine in BBDP-rats, both in mucosa and LMMP. Impaired ER stress response may contribute to the pathogenesis of increased permeability and intestinal dysmotility.