766-1 Angiotensin Converting Enzyme Gene Polymorphism in Acute Myocardial Infarction Patients

Abstract

A polymorphic marker of the ACE gene has been related to circulating ACE activity and to hypertrophic cardiomyopathy, heart failure in general and maybe also to myocardial infarction (MI). This marker is a deletion (D) or insertion (I) of a gene sequence. This generates three different genotypes II, ID and DD. To prospectively study ACE gene polymorphism in consecutive acute MI patients and healthy controls both groups without upper age limits. The genotype frequency is presented in the table. The D allele had approximate frequency of 0.52 in the control group and 0.58 in the acute MI group. The DD/II ratio was higher in the acute MI group (p < 0.05). Odds ratio for the DD genotype was 1.35 (confidence interval 0.94–1.97). ACE genotype II% ID% DD% Acute MI patients (n = 180) 35(19) 80(45) 65(36) Healthy controls (n = 430) 112(26) 192(45) 126(29) The approximate allele frequency as well as odds ratio of the DD genotype is in our study in accordance with other findings (0.53–1.34, Cambien et al, Nature 1992;359:641). ACE gene polymorphism is related to acute MI, its importance in relation to other risk factors needs to be assessed.