757 Clinical efficacy of topical autophagy activator on acne-prone skin

Abstract

Hyperkeratosis in follicular infundibulum, increased sebum formation, and inflammation are major factors in acne pathogenesis. Recent studies about the important roles of autophagy signaling in sebogenesis and epidermal differentiation suggest potential benefits of autophagy activator on acne. In this study, in vitro and clinical studies were performed to investigate the effects of autophagy activator on acne-prone skin. Autophagy signaling in sebocytes SZ95 and keratinocytes was observed and effects of autophagy activating peptide on sebum generation in sebocytes was also investigated.