749 – The factors associated with occurrence of suicidal risk after treatment of ssri in bipolar disorder with their first depressive episode

Abstract

Objective To explore the factors associated with occurrence of suicidal risk after treatment of selective serotonin reuptake inhibitor(SSRI) in bipolar disorder with their first depressive episode.Methods One hundred and seventy seven bipolar patients were enrolled in this retrospective study.Demographic and clinic features between non-occurrence of suicidal risk group and occurrence of suicidal risk group were compared.Stepwise Logistic regression model was used to identify the associated factors.Concordance statistics(i.e.the area under the ROC curve) was used to compute the discrimination of the associated factors,and Hosmer-Lemeshow goodness-of-fit statistic was used to measure the goodness-of-fit.Results One hundred and fifty four patients were included in non-occurrence of suicidal risk group,while twenty three were included in occurrence of suicidal risk group.Compared with non-occurrence of suicidal risk group,the rates of drinking,family history of mood disorder,symptom of irritability,feeling of despair and psychotic symptom were higher in occurrence of suicidal risk group(all P 0.05).Clinical features associated with occurrence of suicidal risk after treatment of SSRI in bipolar disorder were as follows: symptom of irritability(OR = 4.04,95%CI:1.40 ～ 11.67,P 0.05) and psychotic symptom(OR = 6.23,95%CI:1.40 ～ 27.56,P 0.05).Concordance statistics was 0.71 and Hosmer-Lemeshow was 0.58.Conclusion This study has demonstrated that psychotic symptom and symptom of irritability are associated with occurrence of suicidal risk after treatment of SSRI in bipolar disorder,which suggests that these two symptoms might be the predictors of occurrence of suicidal risk in patients with first depressive episode after treatment of SSRI.