747 – Brain-derived neurotrophic factor and b-cell lymphoma leukemia-2 plasma levels in patients with subsyndromal symptomatic depression

Abstract

Objective To explore the relationship between brain-derived neurotrophic factor (BDNF) and B-cell lymphoma Leukemia-2 (Bcl-2) plasma levels in subsyndromal symptomatic depression (SSD) patients. Methods In this case-control study, Enzyme-Linked Immunosorbnent Assay (ELISA) method was used to analysed the differences of BDNF plasma levels between SSD group (n=42) and healthy controls (n=51). At the same time Hamilton Depression Rating Scale-17(HAMD17) were assessed the patients'severity. Result There were significant difference of BDNF plasma levels between SSD group (medium 2.97 ng/ml)and healthy group (medium 3.71ng/ml, z=-2.94, P 0.003). Furthermore, BDNF plasma levels in SSD patients were associated with Hamilton score (r -0.53, P Conclusion The study suggested that the decreased BDNF plasma levels were related with the pathophysiology of SSD and it might reflect the severity of disorder.