Abstract
Objective To explore the relationship between brain-derived neurotrophic factor (BDNF) and subsyndromal symptomatic depression (SSD). Methods In this case-control study, real-time quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) with TaqMan MGB was used to analyze the differences of BDNF gene mRNA expression in peripheral leukocytes between subsyndromal symptomatic depression group and healthy controls. The Hamilton Depression Rating Scale -17 (HAMD17)was used to assess the severity of depression. Results ( 1 ) BDNF gene mRNA expression was (0. 15 ±0.07) in SSD group, (0.25 ±0. 14) in healthy group, and the difference was statistically significant (t =4. 912,P ＜ 0. 01 ). (2) The expression levels of BDNF in SSD patients was negatively correlated with the HAMD17 score (r = -0. 840, P ＜ 0. 001 ). Conclusion The results suggest that the decreased expression of BDNF be related to the pathophysiology of SSD. Key words: Depessive disorder; Brain-derived neurotrophic factor; Leukocytes; Gene expression
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