742: The human fetus maintains normal renal artery blood flow regardless of inflammation

Abstract

REGARDLESS OF INFLAMMATION HUMBERTO AZPURUA, MERT O. BAHTIYAR, EDMUND F. FUNAI, ANTONETTE T. DULAY, SONYA S. ABDEL-RAZEQ, STEPHEN F. THUNG, GUOYANG LUO, IRINA A. BUHIMSCHI, JOSHUA A. COPEL, CATALIN S. BUHIMSCHI, Yale University, Ob./Gyn.R 2) There was no relationship between Doppler indices and GA or EFW in either normal pregnancies or those complicated by PTB. 3) Cord blood IL-6 was higher in IAI (p 0.001); 4) The degree of fetal inflammation by cord IL-6, did not impact on either renal artery PI, RI, S/D ratio or end-diastolic blood flow; 5) A significant inverse relationship between renal artery RI and AFI remained after correcting for membrane status (r -0.33, p 0.02) (Figure). CONCLUSION: This is the first study to demonstrate that the fetus is capable of sustaining normal renal artery hemodynamics regardless of inflammation. We also demonstrate that the resistance of the fetal renal artery impacts on urine output independent of inflammation.