Abstract
The purpose of this study was to investigate seasonal variation in vascular function in people with type 2 diabetes (T2D) who exercise regularly. Fourteen Japanese adults with uncomplicated T2D (5 men and 9 women, age: 65.9 ± 0.9 years, HbA1c: 7.1 ± 0.1%, mean ± SE). All patients exercised at our hospital for 5 years (January 2010-December 2014). Moderate intensity aerobic exercise using a treadmill or bicycle ergometer was performed for 40 min/day (frequency: ≥ 2 days/week). Vascular function, including flow-mediated dilation (FMD), cardio-ankle vascular index (CAVI), and ankle-brachial pressure index (ABI) in each season (spring: March-May, summer: June-August, fall: September-November, winter: December-February) were compared. Variation in FMD throughout the year was 1.0%, and the level in winter was significantly worse than in spring and summer (winter vs. spring and summer: 3.5 ± 0.1% vs. 4.4 ± 0.1% and 4.6 ± 0.1%; p < 0.01 and p < 0.01, respectively) (Figure). However, CAVI and ABI showed no significant change throughout the year. These results suggested that FMD rather than CAVI and ABI might show seasonal variation, even in people with T2D who exercise regularly. It is important to consider these characteristics when managing T2D. Disclosure H. Honda: None. M. Igaki: None.
Published Version
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