Abstract
The vitamin D receptor (VDR) serves as a receptor for active vitamin D hydroxyderivatives. The formation of vitamin D hydroxyderivatives requires the presence of specific cytochrome P450 (CYP) enzymes for vitamin D metabolism. These hydroxyderivatives can be further hydroxylated by CYP27B1 at the C1α-position which increases their affinity for the VDR. However, the role of CYP27B1 in antiproliferative and antifibrotic activities of CYP11A1-derived D3-metabolites is unknown. We tested the action of chemically synthesized vitamin D derivatives: 20,23(OH2D3, 1,20(OH)2D3, or 1,20,23(OH)3D3 and compared to the action of 1,25(OH)2D3 or 20(OH)D3 (non-calcemic compound).
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