732. Individual Differences in the Healthy Population Helps Identify Schizophrenia-Specific Disruptions in Resting State Networks Related to Cognitive Control

Abstract

Cognitive control deficits in schizophrenia (SZ) have been attributed to alterations in prefrontal cortex functional connectivity (as measured by rsfMRI) with executive control (ECN) and default mode (DMN) networks. Healthy comparison groups, however, often have superior cognitive control, meaning differences between groups could be due to poor cognition rather than the presence of a schizophrenia diagnosis. This study used two comparison groups: one with high cognitive control (HCC) and one with low cognitive control (LCC). Using both healthy comparison groups would identify schizophrenia-specific connectivity disruptions (distinctions between SZ and both LCC and HCC groups) and provide a clearer picture of connectivity disruptions underlying poor cognitive control in general.