Abstract
Under physiological conditions, senescent cells (SCs) attract immune cells through secretion of senescence-associated secretory phenotype (SASP), which facilitates immune-mediated clearance of SCs. If SCs are not efficiently cleared, SASP accumulation leads to pathologic dysfunction of nearby non-senescent cells. Human dermal papilla (DP) cells lose their original inductive properties when expanded in in vitro culture, in which senescent cells are never cleared without specific treatment. We discovered that human DP culture accumulated SCs over passaging, which exhibited enlarged nucleocytoplasmic morphology correlating with β-galactosidase and p21 expression.
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