Abstract
Recent advances in generating human organoids from embryoid bodies (EBs) of induced pluripotent stem cells (iPSCs) provide a promising tool for modeling human organ development and disease. A major limitation of current organoids developed in petri-dishes is that the EBs are surrounded symmetrically on all sides by growth factors and extracellular matrix (ECM), leading to uncontrolled spontaneous organization of the tissue. The goal of this study was to precisely guide the self-organization and differentiation of iPSCs-derived EBs into anatomically-relevant skin organoids via ECM cues and spatially-controlled morphogen gradients.
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