Abstract
We report herein the synthesis of 6-oxo-3-phenyl-5,6-dihydropyridazine-1(4H)-carbohydrazide from β-benzoylpropionic acid and carbohydrazide by refluxing in absolute ethanol in presence of sodium acetate. The structure of the newly synthesized compound was established on the basis of IR, 1H-NMR, 13C-NMR and mass spectral data.
Highlights
Pyridazines and their 3-oxo derivatives are important 1,2-diazine-containing heterocyclic compounds having diverse pharmacological activity such as antihypertensive, antidiabetic, anti-inflammatory, antinociceptive and antimicrobial [1–6]
We report the synthesis of 6-oxo-3-phenyl-5,6-dihydropyridazine-1(4H)carbohydrazide from β-benzoylpropionic acid and carbohydrazide by refluxing in absolute ethanol in presence of sodium acetate
Keeping in mind the medicinal utility of pyridazinones, we report the synthesis of 6-oxo-3-phenyl-5,6-dihydropyridazine-1(4H)-carbohydrazide
Summary
Pyridazines and their 3-oxo derivatives (i.e., pyridazinones) are important 1,2-diazine-containing heterocyclic compounds having diverse pharmacological activity such as antihypertensive, antidiabetic, anti-inflammatory, antinociceptive and antimicrobial [1–6]. Abstract: We report the synthesis of 6-oxo-3-phenyl-5,6-dihydropyridazine-1(4H)carbohydrazide from β-benzoylpropionic acid and carbohydrazide by refluxing in absolute ethanol in presence of sodium acetate. The structure of the newly synthesized compound was established on the basis of IR, 1H-NMR, 13C-NMR and mass spectral data. One of the general methods for the synthesis of these compounds involves condensation of 3-aroylpropionic or β-acetylacrylic acid with alkyl or arylhydrazines.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call