Abstract
Lentiviral vectors are a potent gene delivery system that show promise for hematopoietic and neuronal cell applications. However, several safety concerns exist regarding their use. These include the possibility of a replication-competent lentivirus (RCL) arising, which is a particular concern when the parental virus is a human pathogen such as HIV-1. In addition, in common with other integrating vectors, lentiviral vectors have the potential to cause insertional mutagenesis. This can occur directly by gene disruption or read-through transcription from the vector cassette, or indirectly through the action at a distance effects of vector enhancer/promoter elements.
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