Abstract
Introduction. The consequences of Central Nervous System (CNS) injury due to ischemic insult, stroke, or neurotrauma are so severe that novel methods of preventing or minimizing these deficits must be investigated. Gene delivery has the potential to provide both pre-operative neuroprotection before procedures with a predictable high risk, as well as an effective therapy after post-traumatic or ischemic CNS or spinal cord injury. Although viral methods are currently the predominant form of gene delivery, both DNA and mRNA can be delivered by non-viral, cationic lipid-mediated methods.
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