Abstract
Elevated S100 calcium binding protein B (S100B) levels in depressed patients may reflect greater blood brain barrier (BBB) dysfunction, which in turn can facilitate neuroinflammation and impair dopamine neurotransmission. This study tested the hypothesis that higher S100b levels predict poorer outcomes with selective serotonin reuptake inhibitor (SSRI) medications as compared to combination containing dopaminergic antidepressant.
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