668-P: Increased Step Count but No Improvements in Glucose Control: Using CGM as Visualization Tool in Adults with T2D

Abstract

Background: Physical inactivity is common in people with T2D and behavior modification can be difficult due to lack of timely and knowledgeable feedback. Real-time CGM (rtCGM) visualization of impact of efforts on glucose can highlight opportunities for medication and behavior modification to clinicians and individuals. Methods: Glucose and step data in an observational study were collected with Dexcom G6 rtCGMs and activity trackers for 12 weeks in US adults with T2D. Participants did not receive education beyond standard of care. Paired T-tests were used to evaluate changes in step count, % time in range, peak glucose, and hyper- and hypoglycemic events between first and last weeks. Results are presented for the full T2D population (n=183) and a subgroup who increased average daily step count by ≥ 1000 steps (n=63) . Results: Morning steps significantly increased across all participants and steps in all meal-related time periods significantly increased for subgroup (Table 1) . There was not a sustained, significant glucose impact. Conclusion: Adding steps alone, supported by rtCGM, did not result in improvements in glucose. Such visualization provides information for individuals and clinicians to understand opportunities for therapy optimization, including activity and medication regimen. This is promising preliminary data and further research with prescribed intervention is required. Disclosure M.A.Crawford: Employee; Dexcom, Inc. D.R.Cherñavvsky: Employee; Dexcom, Inc. K.Barnard: Advisory Panel; Roche Diabetes Care, Sanofi, Research Support; Dexcom, Inc., Novo Nordisk. X.Wang: None. P.Genge: Employee; Dexcom, Inc. K.Greenawald: None. M.Tressler: Employee; Dexcom, Inc.