669-P: Lower Peak Glucose and Increased Time in Range (TIR) in a CGM-Wearing T2D Population Not Taking Fast-Acting Insulin Shows Value of Real Time–CGM (rtCGM) as a Behavior Change Tool

Abstract

Background: Lifestyle modification is advised for individuals with T2D to improve physical and mental health outcomes. Methods: Glucose data were collected with rtCGMs in an observational 12-week clinical trial in US adults with T2D not taking fast-acting insulin (NIIT) . Participants did not receive education beyond standard of care. Paired T-tests were used to evaluate changes in % TIR 70-180 mg/dL, peak glucose, and hyper- and hypoglycemic events during meal-related time periods (morning, afternoon, evening) between the first and last weeks of CGM wear. Results are presented for the full T2D NIIT population and a subgroup of participants whose TIR increased by ≥ 5% over the study period. Results: Fifty-three (35%) participants improved their TIR by ≥ 5%, in whom TIR and peak glucose were significantly improved and events of severe hyperglycemia were eliminated in meal-related time periods (Table 1) . Conclusion: Lower peak glucose, TIR increasing to target, and elimination of severe hyperglycemic events suggest that participants optimized their glucose during the rtCGM wear period through behavior modification. Longitudinal research that collects contextual behavioral and self-learning information alongside CGM data can provide further insight into how rtCGM operates as a behavior change tool. Disclosure M.A.Crawford: Employee; Dexcom, Inc. D.R.Cherñavvsky: Employee; Dexcom, Inc. K.Barnard: Advisory Panel; Roche Diabetes Care, Sanofi, Research Support; Dexcom, Inc., Novo Nordisk. X.Wang: None. P.Genge: Employee; Dexcom, Inc. K.Greenawald: None. M.Tressler: Employee; Dexcom, Inc.