Abstract
To characterize mechanisms leading to a dietary evoked increase of sucrase (Sa) and lactase (La) activity by dietary intake of disaccharides [sucrose (S) or lactose (L)], two-month-old rats were fed for 7 days a low carbohydrate diet (LC) [BBA 676:108], then for the next 3 to 72 hours, they were force fed a S or L diet (20 or 40 cal%). Activity of La and Sa increased after 3 hours, but only Sa continued to increase for the next 48 hours. The effect of variation of carbohydrate intake on Sa and La after 12 hours is summarized below. Whereas Sa increased with greater intake of S and L, La did not. Determination of changes of enzyme activity along the height of the villus-crypt columns showed that the increase of Sa began at the lower villus, but the increase of La occurred along the entire villus. Conclusion. Differences in response of Sa and La to S arid L intake (time, dose, locus) suggest that the increase of both disaccharidases evoked by dietary intake of S or L is the result of different mechanisms.
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