Abstract
Liver is a highly metabolically active organ that has high oxygen and nutrient demands. Even though a healthy liver has the capacity to regenerate, damage to the organ may result in mortality if the hepatic function is not supported. Because the current treatment methods for liver failure are limited, tissue engineering has offered tools to develop alternative treatment options. One common aspect of tissue engineering approaches for liver regeneration is the use of either synthetic or natural materials to provide an environment that mimics the physiological conditions and architecture of the organ. Here, we provide background on the extracellular environment in the liver and summarize materials and fabrication methods used for scaffold fabrication that support liver regeneration.
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