(635) - MicroRNA-1202 Is a Candidate Biomarker To Assist Selection of Patients for Therapy With a Left Ventricular Assist Device

Abstract

s S235 level of SDF-1a at explant. CXCR4 expression remained unchanged following CF-LVAD support, however it tended to be lower in DM pts suggesting an impaired ability in endogenous stem cell mobilization. Conclusion: Chronic LVAD therapy down regulates SDF-1a expression likely as a consequence of effective unloading. DM pts exhibit the lowest levels of SDF-1a. Low SDF-1a expression may lead to impaired mobilization of endogenous stem cells and negatively affect myocardial recovery. Whether therapeutic SDF-1 administration in this setting could promote recovery should be further investigated.