Abstract
Genetic factors contribute to individual differences in pain sensitivity in humans and nociception in animals. Molecular and behavioral characterization of mouse genetic reference populations including recombinant inbred (RI) mice can be used to determine the responsible genes, their mechanistic effects, and the specific tissues involved. High-throughput behavioral testing protocols are required for efficient assessment of mouse nociception in large populations and mutant screens. These often controversial protocols involve repeated testing, which via habituation to stressors or anticipation of aversive stimuli may interact with organismic variables including sex to mimic or confound the effects of genetic variation.
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