626-P: Integrated Approach of Yoga Therapy (IAYT) Improves Cerebrovascular Functions and Prefrontal Hemodynamic Activities Related to Cognition in Type 2 Diabetes

Abstract

The present study aimed to assess the integrated approach of yoga therapy (IAYT) effect on cerebrovascular reactivity in middle cerebral artery (MCA), prefrontal cortex (PFC) oxygenation and cognitive functions in patients with T2DM. Method: 75 patients were randomized to the IAYT group [n=38; 07 female; mean age 52.95 (8.20) years] and the waitlist control group [n=37; 06female; mean age (SD) 49.62 (10.94) years]. The cerebral blood flow and prefrontal hemodynamic activities were assessed using transcranial doppler and functional near-infrared spectroscopy, respectively, during resting and cognitive performance. IAYT group participants received 3 months of intervention and assessments were done at baseline (0-week), mid (after 6-week), and post (after 12-week). Results: After a 12-week intervention, participants of the yoga group showed improved accuracy and reaction time in a 2-back condition of the working memory task, and the scores of the Corsi Block Tapping task. Further, cerebrovascular changes were observed in the middle cerebral artery, which showed increased peak systolic velocity, mean blood flow velocity, end-diastolic velocity, and breath-holding index after 12-week yoga practice. The oxygenation was also higher at dorsolateral, dorsomedial, and ventromedial and orbitofrontal PFC in the 12th week of the yoga practitioners group compared to the control group. Moreover, during 2-back working memory task, yoga group participants demonstrated increased oxygenation at dorsolateral PFC compared to pre and higher oxygenation at dorsolateral, ventrolateral, ventromedial and orbitofrontal PFC compared to control group. Conclusion: The results suggest that IAYT practice may improve cognitive functions by improving cerebral blood flow through the middle cerebral artery and hemodynamic activities in the prefrontal regions in patients with T2DM. Disclosure D.Singh: None. C.Kaligal: None. V.M: None. A.Kanthi: None. Funding Ministry of Ayush, Government of India (Z.280152092015-HPC(EMR)-AYUSH)