Abstract
Aging of human skin results from genetic (= intrinsic) factors, which affect all parts of human skin, and non-genetic (= extrinsic) factors such as solar radiation, which impact only selected skin areas. For both, age-dependent changes in dermal fibroblasts are relevant. To better understand the relationship between intrinsic and extrinsic skin aging, we analyzed dermal skin fibroblasts which were obtained from intrinsically (NHDFINT) versus extrinsically (NHDFEXT) aged human skin of the same donors of one of three age groups (young, middle-aged and old).
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