Abstract
Tabled 1Percentage of Inhibition of lentiviral transduction by anti-HIV-1 agentsDays post RxUntreatedPMPA 5 uMAZT 100 uMIndinavir 1 uMDay 106 98 62 7Day 302 88 30Day 502 77 90Day 9081 90 Open table in a new tab Tabled 1Effect of AZR and PMPA on hematopoietic progenitor colonies in methylcelluloseDays post RxmockuntreatedPMPA 5 uMAZT 100 uMDay 11091021131 4Day 31371247 23 9Day 59 21658 4108 Open table in a new tab In conclusion, PMPA and AZT exposure pre-treatment can significantly inhibit tbransduction efficiency by lentivirus vectors, and this effect lasts for up to one week. There is little effect after 2 hours post-transduction. In gene transfer research studies involving HIV/AIDS patients, it is warranted to stop PMPA, AZT, and other NRTI therapies before blood cells are collected for the research transductions. In conclusion, PMPA and AZT exposure pre-treatment can significantly inhibit tbransduction efficiency by lentivirus vectors, and this effect lasts for up to one week. There is little effect after 2 hours post-transduction. In gene transfer research studies involving HIV/AIDS patients, it is warranted to stop PMPA, AZT, and other NRTI therapies before blood cells are collected for the research transductions.
Published Version
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