Abstract
Hypertrophic scars (HTS) and keloids are characterized by excessive synthesis and abnormal collagen deposition during wound healing. One of the most important proteins in collagen triple helix formation and stabilization is HSP47, which is highly expressed in pathological scar tissue. Here we report for the first time the discovery of a small molecule HSP47 inhibitor, INV-10000001 (INV-001) which was identified via virtual screening. This was confirmed by the collagen turbidity assay which measures the function of HSP47 and by the surface plasmon resonance assay.
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