Abstract
Efficiency and specificity of gene delivery to tumors are major concerns in cancer gene therapy. We have previously used regional ionizing radiation to improve adenovirus uptake and to enhance gene expression in intrahepatic tumors (Zhang, M, et al. Mol Ther. 2003, 8:21-28; Qian, J, et al. Cancer Res. 2005, 65:5493-5497). However, non-specific gene expression and cytotoxicity in normal liver is still inevitable. Here, we explore the potentials of radiation in improving gene delivery by a virus-mimicking nanostructure complex, transferrin (Tf)-cationic liposome-DNA complex (Tf- lipoplex) (Liang, Xu, et al.
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