Abstract
The production, distribution and use of electricity can generate low frequency electric and magnetic fields (50-60Hz). Considering that some studies showed adverse effects on pancreatic β-cells exposed to these fields; the present study aimed to analyze the effects of 60Hz electric fields on membrane potential during the silent and burst phases in pancreatic β-cells using a mathematical model. Sinusoidal 60Hz electric fields with amplitude ranging from 0.5 to 4mV were applied on pancreatic β-cells model. The sinusoidal electric field changed burst duration, inter-burst intervals (silent phase) and spike sizes. The parameters above presented dose-dependent response with the voltage amplitude applied. In conclusion, theoretical analyses showed that a 60Hz electric field with low amplitudes changes the membrane potential in pancreatic β-cells.
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