Abstract
Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme that plays a relevant role in the mitochondrial function. TSTs are enzymes widely distributed in both prokaryotes and eukaryotes and are involved in several biochemical processes such as the cyanide detoxification, restoration of iron–sulfur clusters, redox system maintenance, the mitochondrial import of 5S rRNA, and transport of sulfur and selenium in biologically available forms. Recent studies have shown a relevant role of TST in metabolic diseases opening a new interest in this enzyme as a target for therapeutical applications. This chapter describes the biological role of this class of enzymes, underlining their structural and functional aspects, their relevance in cellular metabolism, and their biotechnological applications.
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