Abstract
Dopamine receptors share structural elements suggesting they belong to a superfamily classified as G-protein-coupled receptors. The concept of heterogeneity of dopamine receptors was originated in 1978 on the basis of functional and pharmacological evidences. It is now accepted that the original classification in D-1 and D-2 receptors is not adequate to account for all the experimental findings regarding the action of dopamine. This review will focus on the main lines of evidence suggesting the existence of multiple types of dopamine D-2 receptors. Furthermore, the functional relevance in compensatory processes of the dopamine D-2 receptor viewed as a pliant structure composed of several distinct proteins that allosterically interact with each other will be discussed.
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