Abstract
The work of Dewey (1977), in Australia, showed that the oral administration of cupric oxide wire (CuON), in lengths of between 5-10 mm and a mean diameter of 0.5 mm, at a dosage rate of 10 g in a gelatin capsule to mature sheep, produced a steady increase in liver copper (Cu) concentrations over 16 days to levels over 1000 mg/kg DM above the initial levels. The 'needles' lodged primarily between the abomasal folds and, by 64 days, were no longer detectable. In grazing conditions, a dose of 20 g was administered to sheep. At neither dosage level were deleterious effects noted. Suttle (1981) administered 0.5 g CuON to hypocupraemic ewes maintained on a Cu-deficient diet and alleviated hypocupraemia for 111 days when the diet was supplemented with molybdenum (Mo) and sulphur (S), and 301 days when the diet was not so supplemented.
Published Version
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