Abstract
BACKGROUND CONTEXT: Growth/differentiation factor-5 (GDF-5) is a member of a divergent subgroup of the bone morphogenetic protein (BMP) family. Members in this subgroup share 40–50% protein sequence homology with the BMP-2 and BMP-7 subgroups. Expression of GDF-5 is required for proper skeletal patterning and joint development in the vertebrate limb, and null mutations result in brachydactyly syndromes in both animal and man. Type I collagen and hydroxyapatite are the predominant components of bone. Fabricated from these osteoconductive components is a mineralized collagen matrix (further referred to as matrix) comparable in composition to natural bone. This matrix, combined with bone marrow aspirate as a source of osteogenic stimuli, is used clinically as a bone grafting material to fill bony voids. In previous animal studies, this matrix combined with rhGDF-5 demonstrated osteoinductive activity and promoted new bone formation in various bony defect and spine fusion models.
Published Version
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