589-P: Impact of Sedentary Behavior on Glycemic Profiles by Real-Time Continuous Glycemic Monitoring in People with Type 1 Diabetes

Abstract

The purpose of this study was to examine the association between sedentary behavior (SB) and glycemic profiles by real-time continuous glycemic monitoring (rt-CGM) in people with type 1 diabetes (T1D). Fifty-eight Japanese adults with T1D were assessed and analyzed in this study (8 men and 50 women, age: 43.5 [32.0-54.0], HbA1c: 7.1 [6.7-7.8], median [25%-75% quartiles]). The type of physical activity (PA) measured using a triaxial accelerometer was defined according to intensity: SB (≤1.5 metabolic equivalents [METs], light-intensity PA (1.6-2.9 METs), and moderate-to-vigorous-intensity PA (≥3.0 METs). Total SB per day was 506.4 (442.2-575.9) min. A longer prolonged (≥30 min) SB and fewer steps per day were associated with higher mean 24-h sensor glucose values, higher time above range, and lower time in range (prolonged SB: ρ = 0.662 [p < 0.01], 0.627 [p < 0.01], and −0.591 [p < 0.01]; steps: ρ = −0.405 [p < 0.01], −0.401 [p < 0.01], and 0.327 [p < 0.05], respectively) (Figure). Conversely, total SB and other PA had no association with glycemic profiles. These results implied that more time spent on prolonged SB and fewer steps might contribute to the deterioration of glycemic profiles by rt-CGM in people with T1D. It is important to consider these characteristics when managing T1D. Disclosure H.Honda: None. N.Hashimoto: None. M.Zenibayashi: None. T.Takeuchi: None. A.Yamamoto: None. Y.Hirota: Other Relationship; Lilly, Sanofi K.K., Terumo Corporation, Sumitomo Dainippon Pharma Co., Ltd., Research Support; Sumitomo Dainippon Pharma Co., Ltd.