Abstract
Short interfering double-stranded RNA (siRNA) that mediate specific gene silencing through RNA interference (RNAi) are widely used to study gene function in vitro and this technology is now being applied to animal models in vivo . Synthetic siRNA are also being developed for a wide variety of clinical applications although to date, approved clinical trials are restricted to local administration in occular indications due largely to the lack of systemic delivery vehicles appropriate for use with therapeutic siRNA.
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