57: Hypoalbuminemia Severity Predicts Intradialytic Parenteral Nutrition (IDPN) Effectiveness in Hemodialysis Patients

Abstract

Hypoalbuminemia Severity Predicts Intradialytic Parenteral Nutrition (IDPN) Effectiveness in Hemodialysis Patients Arezu Dezfuli, MD, Michelle Ricker, RD; Deborah Scholl, RD; Stanley M Lindenfeld, MD; and Kamyar Kalantar-Zadeh, MD PhD Harold Simmons Center for Kidney Disease Research& Epidemiology, Harbor-UCLA, Torrance, CA; and Pentec Health, Boothwyn, PA Background: Intradialytic parenteral nutrition (IDPN) is currently used infrequently to correct hypoalbuminemia in maintenance hemodialysis (MHD) patients (pts). Correcting hypoalbuminemia may significantly improve survival in MHD pts (Kalantar-Zadeh et al, NDT 2005; 20:1880-8). We hypothesized that IDPN responders, i.e., those whose baseline serum albumin [S-albumin] increased persistently during IDPN, have unique characteristics. Methods: In a recent cohort of MHD pts who had received IDPN through Pentec Health, predictors of IDPN response were examined using multivariate logistic regression. Results: A total of 196 MHD patients underwent IDPN for 5.8±2.4 mo between 2002 and 2006. Baseline serum albumin (2.68±0.47 g/dL) was lower in the IDPN responders than the non-responders (see table): MHD patients’ characteristics Responder (n=142) Nonresponder (n=54) p-value