Abstract
The structure of the lower part of the hair follicle undergoes cyclic formation and decay. During the anagen, the hair follicle is surrounded by capillary blood vessels that supply oxygen and nutrients. However, the blood vessels disappear during the catagen, and the oxygen concentration in the hair follicle is expected to decrease significantly. There is little information on the response of the human DPCs to the hypoxic condition of the hair follicle. In this research, we evaluated hypoxic response and its influence of the expression of TGF-β2 and BMP4 in dermal papilla cells (DPCs), which cells are the command center of the hair cycle.
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