Abstract
The purpose of this study was to measure cerebral blood flow (CBF), cerebral blood volume (CBV) and its response to changes in arterial carbon dioxide tension (CBVR) by NIRS in 21 term newborn infants who had suffered birth asphyxia. All had clinical and biochemical (base deficit ≥ 15 mmol/l) evidence of asphyxia and were studied during ihc first 24 hours. Eight of the 21 infants died and neurodevelopmental examination in survivors at one year of age showed that 7 had major neurological impairments; the remaining 6 infants were normal or had minor impairments. Results (mean ± SEM) were as follows: Values for CBF and CBV were significantly higher than previously defined normal values and for CBVR lower. The extern of the abnormalities was related to the severity of adverse outcome (ANOVA p<0.05).
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