Abstract
Oriented cell division is a key regulator of cell fate and linked to the positioning of the spindle in mitosis. However, in mammals the cues that determine planar versus perpendicular positioning of the spindle remain largely unclear. One candidate is the polarity protein atypical protein kinase C (aPKC)l, which regulates cell fate and spindle orientation in vivo in the epidermis. To study how aPKC controls mitotic spindle orientation, we developed a minimal keratinocyte culture system in which planar spindle positioning occurs in the absence of intercellular adhesive polarity cues.
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